WebJan 6, 2024 · The risk of severe side effects tends to increase the longer you take prednisone. The prolonged use (or overuse) of prednisone is associated with an … WebSep 9, 2024 · With long-term use, prednisone can also cause changes in body fat, leading to fat deposits at the back of the neck or around the belly. Verywell / Emily Roberts. Reducing salt intake can prevent water retention that contributes to facial mooning. Watching fat and calorie intake can help to prevent weight gain.
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