WebInvolved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. WebJul 9, 2024 · PDGF signaling in CAFs has been shown to act as a determinant of the molecular subtype in BC ( 18 ). Previous studies have also reported that PDGFRβ expression in fibroblasts of BC patients is …
GRB7 (growth factor receptor bound protein 7)
WebJan 17, 2024 · Reactome is an open source and open access resource, available to anyone and covered by two Creative Commons licenses: the terms of the Creative Commons Public Domain (CC0) License apply to all Reactome annotation files, e.g. identifier mapping data, specialized data files, and interaction data derived from Reactome; the terms of the … WebAffected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, … high rise invasion english dub episode 1
PDGFRB platelet derived growth factor receptor beta [ (human)]
WebPlatelet-derived growth factor (PDGF) is a potent mitogen, chemoattractant, and survival factor for cells of mesenchymal origin (such as fibroblasts, smooth muscle cells, or glial cells). PDGF exists as a number of isoforms that initiate signaling via two closely related receptor tyrosine kinases named α- and β-receptors. WebFig 1: Enrichment plot: REACTOME_SIGNALING_BY_PDGF Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List. PROBE GENE SYMBOL GENE_TITLE RANK IN GENE LIST RANK METRIC SCORE RUNNING ES CORE ENRICHMENT; 1: SOS1: SOS1 Entrez, Source: son of sevenless homolog 1 (Drosophila) 18: 9.469: 0.0733: … WebPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells … high rise invasion ep 5